S11d, Supplementary Material online. Studying the expression of the mitfa gene, we found a paralog of mitfa, in the eye. The expression of mitfb was higher than that of mitfa in the attention of both albino and wild type fish, and, interestingly, mitfb was more highly expressed in eyes of albino than wild type fish supplementary fig. S11d, Supplementary Material online. It is likely that mitfb has critical applications for retinal pigment formation and shows compensatory outcomes on mitfa in albino fish phenotype. Interestingly, this mechanism is per the nacre mutant of zebrafish Danio rerio, which is also a mutation of mitfa and in addition has black eyes Lister et al.