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The obtained experimental diabetes in laboratory animals just like rats is a pretty good model to check oxidative stress due to continual hyperglycemia, which thereby depresses the engaging in of the antioxidant protection system and induces the technology of free radicals de novo. The free radicals thus formed react with all biological ingredients. The reactions with these elements of the cell membrane cause lipid peroxidation 26. The liver consists of a high content material fabric of antioxidant enzymes just like catalase and superoxide dismutase that may trap these free radicals. Compounds with antioxidant homes could be able of reduce the recognition of free radicals. The lipid peroxidation in diabetes leads to higher plasma and hepatic levels of MDA and hydroperoxides.