W. built vectors. L. W. , F. S. These data show that the distribution of red pigments is a polygenic trait. Interestingly, the QTLs found for tail had no overlap with those for head, implying the distribution of red pigments in various body sections is determined by various genetic loci. Although we did not identify the genes underlying red pigment distribution, our study adds first insights for a far better knowing of a variety of pigmentation styles from a polygenic perspective. Genetic mapping of distribution of red pigments xanthophores and fin spotting pattern, albino mutant, and validation of mitfa gene as the candidate causal gene for albino mutant using CRISPR/Cas9 knockout. A Variation of the distribution of red pigments in caudal fin and head sections. B QTL mapping and evaluation for distribution of red pigments in caudal fin and head sections, where blue and green horizontal lines indicate LOD cutoff values of chromosome and genome wide significance, respectively.